Article
Shared mechanisms across the major psychiatric and neurodegenerative diseases.
Nature communications - 26 Jul 2022
Wingo Thomas S, Liu Yue, Gerasimov Ekaterina S, Vattathil Selina M, Wynne Meghan E, Liu Jiaqi, Lori Adriana, Faundez Victor, Bennett David A, Seyfried Nicholas T, Levey Allan I, Wingo Aliza P
Abstract excerpt
Several common psychiatric and neurodegenerative diseases share epidemiologic risk; however, whether they share pathophysiology is unclear and is the focus of our investigation. Using 25 GWAS results and LD score regression, we find eight significant genetic correlations between psychiatric and neurodegenerative diseases. We integrate the GWAS results with human brain transcriptomes (n = 888) and proteomes...
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