Article
Effect of the p53 P72R Polymorphism on Mutant TP53 Allele Selection in Human Cancer.
Journal of the National Cancer Institute - 4 Sept 2021
De Souza Cristabelle, Madden Jill, Koestler Devin C, Minn Dennis, Montoya Dennis J, Minn Kay, Raetz Alan G, Zhu Zheng, Xiao Wen-Wu, Tahmassebi Neeki, Kathi Harikumara R, Nelson Nina, Karnezis Anthony N, Chien Jeremy
Abstract excerpt
BACKGROUND: TP53 mutations occur in more than 50% of cancers. We sought to determine the effect of the intragenic P72R single nucleotide polymorphism (SNP; rs1042522) on the oncogenic properties of mutant p53. METHODS: P72R allelic selection in tumors was determined from genotype calls and a Gaussian distributed mixture model. The SNP effect on mutant p53 was determined in p53-negative cancer cell lines....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.