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Article

TP53 Codon 72 Polymorphism Impacts Macrophage Activation through Reactive Oxygen Species-Dependent Cell Signaling Alterations.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2024

Silwal Ashok, Reese Britney, Patel Bhaumik, Li Yan, Kolev Martin V, La-Beck Ninh M, Karbowniczek Magdalena M, Markiewski Maciej M

Abstract excerpt

The role of the most common TP53 single-nucleotide polymorphism (SNP) at codon 72, which encodes for proline (P72) or arginine (R72), in the regulation of the immune system has not yet been thoroughly explored. We found that this SNP contributes to aggravated inflammatory response in COVID-19 patients resulting from biased macrophage activation. R72-P53 inhibits mitochondrial manganese superoxide dismutase,...

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Identifiers

PMID: 39451031
DOI: 10.4049/jimmunol.2400212
PMCID: PMC11611636

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