The P72R Polymorphism in R248Q/W p53 Mutants Modifies the Mutant Effect on Epithelial to Mesenchymal Transition Phenotype and Cell Invasion via CXCL1 Expression.

doi:10.3390/ijms21218025

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The P72R Polymorphism in R248Q/W p53 Mutants Modifies the Mutant Effect on Epithelial to Mesenchymal Transition Phenotype and Cell Invasion via CXCL1 Expression.

International journal of molecular sciences - 28 Oct 2020

De Souza Cristabelle, Madden Jill A, Minn Dennis, Kumar Vigneshwari Easwar, Montoya Dennis J, Nambiar Roshni, Zhu Zheng, Xiao Wen-Wu, Tahmassebi Neeki, Kathi Harikumara, Nelson Nina, Karnezis Anthony N, Chien Jeremy

Abstract excerpt

High-grade serous carcinoma (HGSC), the most lethal subtype of epithelial ovarian cancer (EOC), is characterized by widespread TP53 mutations (>90%), most of which are missense mutations (>70%). The objective of this study was to investigate differential transcriptional targets affected by a common germline P72R SNP (rs1042522) in two p53 hotspot mutants, R248Q and R248W, and identify the mechanism through which...

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PMID: 33126568
DOI: 10.3390/ijms21218025
PMCID: PMC7662892

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