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Article

Germline variation in TP53 regulatory network genes associates with breast cancer survival and treatment outcome.

International journal of cancer - 1 May 2013

Jamshidi Maral, Schmidt Marjanka K, Dörk Thilo, Garcia-Closas Montserrat, Heikkinen Tuomas, Cornelissen Sten, van den Broek Alexandra J, Schürmann Peter, Meyer Andreas, Park-Simon Tjoung-Won, Figueroa Jonine, Sherman Mark, Lissowska Jolanta, Keong Garrett Teoh Hor, Irwanto Astrid, Laakso Marko, Hautaniemi Sampsa, Aittomäki Kristiina, Blomqvist Carl, Liu Jianjun, Nevanlinna Heli

Abstract excerpt

Germline variation in the TP53 network genes PRKAG2, PPP2R2B, CCNG1, PIAS1 and YWHAQ was previously suggested to have an impact on drug response in vitro. Here, we investigated the effect on breast cancer survival of germline variation in these genes in 925 Finnish breast cancer patients and further analyzed five single nucleotide polymorphisms (SNPs) in PRKAG2 (rs1029946, rs4726050, rs6464153, rs7789699) and...

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Share to AMP-Activated Protein Kinases
Share to Antineoplastic Agents, Hormonal
Share to Carcinoma, Ductal, Breast
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Source

Open in PubMed Open full text

Identifiers

PMID: 23034890
DOI: 10.1002/ijc.27884
PMCID: PMC4159753

Genes

PRKAG2
MDM2
CCNG1
PIAS1
YWHAQ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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