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Article

The Pro allele of the p53 codon 72 polymorphism is associated with decreased intratumoral expression of BAX and p21, and increased breast cancer risk.

PloS one - 1 Jan 2012

Proestling Katharina, Hebar Alexandra, Pruckner Nina, Marton Erika, Vinatzer Ursula, Schreiber Martin

Abstract excerpt

BACKGROUND: The TP53 Arg72Pro polymorphism encodes two p53 variants with different biochemical properties. Here we investigated the impact of this polymorphism on the expression of key p53 target genes in a panel of human breast carcinomas, breast cancer risk, and age at onset. METHODOLOGY/PRINCIPAL FINDINGS: The Arg72Pro polymorphism was genotyped in 270 breast cancer patients and 221 control subjects. In...

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Share to bcl-2-Associated X Protein
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Gene Expression Regulation, Neoplastic

Share to Proportional Hazards Models

Share to Real-Time Polymerase Chain Reaction

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Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 23071787
DOI: 10.1371/journal.pone.0047325
PMCID: PMC3468577

Genes

BAX
MDM2
PERP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Pro allele of the p53 codon 72 polymorphism is associated with decreased intratumoral expression of BAX and p21, and increased breast cancer risk.PMID 23071787Read ↗

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