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Article

SNPing away at mutant p53 activities.

Genes & development - 1 Feb 2018

Ortiz Guadalupe J, Lozano Guillermina

Abstract excerpt

A delicate balance in the levels of proteins that regulate the p53 tumor suppressor pathway exists such that subtle changes alter p53 tumor suppressor activity and cancer risk. Many single-nucleotide polymorphisms (SNPs) in the p53 pathway alter p53 transcriptional activity and are associated with cancer risk. In addition, some SNPs influence the gain-of-function (GOF) activities of mutant p53 through unknown...

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Identifiers

PMID: 29491132
DOI: 10.1101/gad.312934.118
PMCID: PMC5859960

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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