Article
A phosphoinositide-mediated switch of GET pathway receptor dimerization in Arabidopsis.
Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 2025
Zhang Lei, Struß Aron, Qin Miaojing, Dombrowski Annika, Li Tingting, Viebahn Stefanie, Mehlhorn Dietmar, Grefen Christopher
Abstract excerpt
The Guided Entry of Tail-Anchored Proteins (GET) pathway facilitates the insertion of tail-anchored (TA) proteins into the ER membrane, but its regulation in plants remains unclear. In Arabidopsis, we identify phosphatidylinositol 4-phosphate (PI4P) as an anchor that brings the receptors AtGET1 and AtGET2 into proximity within the ER membrane. AtGET2 binds PI4P via an arginine residue in its transmembrane domain....
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