Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

OLIG2 maintenance is not essential for diffuse intrinsic pontine glioma cell line growth but regulates tumor phenotypes.

Neuro-oncology - 1 Jul 2021

Liao Yunfei, Luo Zaili, Deng Yaqi, Zhang Feng, Rao Rohit, Wang Jiajia, Xu Lingli, Kumar Shiva Senthil, Sengupta Satarupa, DeWire-Schottmiller Mariko, Berry Kalen, Garrett Matthew, Fouladi Maryam, Drissi Rachid, Lu Qing Richard

Abstract excerpt

BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is a pediatric lethal high-grade brainstem glioma with no effective therapies. OLIG2 (oligodendrocyte transcription factor 2) was reported to be critical for the growth of a DIPG cell line CCHMC-DIPG-1. Surprisingly, we found that the CCHMC-DIPG-1 cells express little OLIG2 and exhibit a mesenchymal phenotype, which raised a question regarding the role of OLIG2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Stem Neoplasms
Share to Cell Line

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Oligodendrocyte Transcription Factor 2

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 33539525
DOI: 10.1093/neuonc/noab016
PMCID: PMC8661399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

OLIG2 maintenance is not essential for diffuse intrinsic pontine glioma cell line growth but regulates tumor phenotypes.PMID 33539525Read ↗

The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomasSemantic proximity Read ↗

Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma.Semantic proximity Read ↗

Orchestrating the Acquisition of Oligodendrocyte Precursor Cell versus Olfactory Bulb Interneuron Fates through <i>Olig1/2</i> during Mammalian Cortical Gliogenesis and GliomagenesisSemantic proximity Read ↗

The emerging role of NG2 in pediatric diffuse intrinsic pontine glioma.Semantic proximity Read ↗

Cellular and molecular characterization of IDH1-mutated diffuse low grade gliomas reveals tumor heterogeneity and absence of EGFR/PDGFRα activation.Semantic proximity Read ↗

Isocitrate Dehydrogenase Mutations Are Associated with Different Expression and DNA Methylation Patterns of OLIG2 in Adult Gliomas.Semantic proximity Read ↗

Clinical, imaging, and molecular analysis of pediatric pontine tumors lacking characteristic imaging features of DIPG.Semantic proximity Read ↗

Transcription factors ASCL1 and OLIG2 drive glioblastoma initiation and co-regulate tumor cell types and migration.Semantic proximity Read ↗

Head of the Class: OLIG2 and Glioblastoma Phenotype.Semantic proximity Read ↗

Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltrationSemantic proximity Read ↗

Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine gliomaSemantic proximity Read ↗

Candidate pathways for promoting differentiation or quiescence of oligodendrocyte progenitor-like cells in glioma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.