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Candidate pathways for promoting differentiation or quiescence of oligodendrocyte progenitor-like cells in glioma.

Cancer research - 15 Sept 2012

Dougherty Joseph D, Fomchenko Elena I, Akuffo Afua A, Schmidt Eric, Helmy Karim Y, Bazzoli Elena, Brennan Cameron W, Holland Eric C, Milosevic Ana

Abstract excerpt

Platelet-derived growth factor receptor alpha-positive oligodendrocyte progenitor cells (OPC) located within the mature central nervous system may remain quiescent, proliferate, or differentiate into oligodendrocytes. Human glioblastoma multiforme tumors often contain rapidly proliferating oligodendrocyte lineage transcription factor 2 (Olig2)-positive cells that resemble OPCs. In this study, we sought to...

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Brain Neoplasms
Cell Differentiation
Glioma
Microarray Analysis
Neoplastic Stem Cells

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Oligodendroglia

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PMID: 22865458
DOI: 10.1158/0008-5472.CAN-11-2632
PMCID: PMC3543775

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