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Article

The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas

15 Dec 2016

Abstract excerpt

Background: Diffuse intrinsic pontine glioma (DIPG) is a high-grade brainstem glioma of children with dismal prognosis. There is no single unifying model about the cell of origin of DIPGs. Proliferating cells in the developing human and mouse pons, the site of DIPGs, express neural stem/progenitor cell (NPC) markers, including Sox2, nestin, vimentin, Olig2, and glial fibrillary acidic protein, in an overlapping...

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PMID: 28339768
DOI: 10.1093/neuonc/now299

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