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Article

The emerging role of NG2 in pediatric diffuse intrinsic pontine glioma.

Oncotarget - 20 May 2015

Yadavilli Sridevi, Scafidi Joseph, Becher Oren J, Saratsis Amanda M, Hiner Rebecca L, Kambhampati Madhuri, Mariarita Santi, MacDonald Tobey J, Codispoti Kari-Elise, Magge Suresh N, Jaiswal Jyoti K, Packer Roger J, Nazarian Javad

Abstract excerpt

Diffuse intrinsic pontine gliomas (DIPGs) have a dismal prognosis and are poorly understood brain cancers. Receptor tyrosine kinases stabilized by neuron-glial antigen 2 (NG2) protein are known to induce gliomagenesis. Here, we investigated NG2 expression in a cohort of DIPG specimens (n= 50). We demonstrate NG2 expression in the majority of DIPG specimens tested and determine that tumors harboring histone 3.3...

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PMID: 25987129
DOI: 10.18632/oncotarget.3716
PMCID: PMC4494928

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