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Article

Protein Kinase A: A Master Kinase of Granulosa Cell Differentiation.

Scientific reports - 21 Jun 2016

Puri Pawan, Little-Ihrig Lynda, Chandran Uma, Law Nathan C, Hunzicker-Dunn Mary, Zeleznik Anthony J

Abstract excerpt

Activation of protein kinase A (PKA) by follicle stimulating hormone (FSH) transduces the signal that drives differentiation of ovarian granulosa cells (GCs). An unresolved question is whether PKA is sufficient to initiate the complex program of GC responses to FSH. We compared signaling pathways and gene expression profiles of GCs stimulated with FSH or expressing PKA-CQR, a constitutively active mutant of PKA....

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Source

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Identifiers

PMID: 27324437
DOI: 10.1038/srep28132
PMCID: PMC4914995

Genes

FOXO1
GAB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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