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Article

G-Protein α-Subunit Gsα Is Required for Craniofacial Morphogenesis.

PloS one - 1 Jan 2016

Lei Run, Zhang Ke, Wei Yanxia, Chen Min, Weinstein Lee S, Hong Yang, Zhu Minyan, Li Hongchang, Li Huashun

Abstract excerpt

The heterotrimeric G protein subunit Gsα couples receptors to activate adenylyl cyclase and is required for the intracellular cAMP response and protein kinase A (PKA) activation. Gsα is ubiquitously expressed in many cell types; however, the role of Gsα in neural crest cells (NCCs) remains unclear. Here we report that NCCs-specific Gsα knockout mice die within hours after birth and exhibit dramatic craniofacial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26859889
DOI: 10.1371/journal.pone.0147535
PMCID: PMC4747491

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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