Article
Early Developmental EEG and Seizure Phenotypes in a Full Gene Deletion of Ubiquitin Protein Ligase E3A Rat Model of Angelman Syndrome.
eNeuro - 1 Jan 2000
Born Heather A, Martinez Luis A, Levine Amber T, Harris Sarah E, Mehra Shubhangi, Lee Wai Ling, Dindot Scott V, Nash Kevin R, Silverman Jill L, Segal David J, Weeber Edwin J, Anderson Anne E
Abstract excerpt
Angelman syndrome (AS) is a neurodevelopmental disorder with unique behavioral phenotypes, seizures, and distinctive electroencephalographic (EEG) patterns. Recent studies identified motor, social communication, and learning and memory deficits in a CRISPR engineered rat model with a complete maternal deletion of the Ube3a gene. It is unknown whether this model recapitulates other aspects of the clinical...
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