Article

Abnormal electrophysiological phenotypes and sleep deficits in a mouse model of Angelman Syndrome

2021-01-25

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Angelman Syndrome (AS) is a rare genetic disorder characterized by impaired communication, motor and balance deficits, intellectual disabilities, recurring seizures and abnormal sleep patterns. The genetic cause of AS is neuronal specific loss of expression of <italic>UBE3A </italic>(ubiquitin-protein ligase E6-AP), an imprinted gene. Seizure and sleep disorders...

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Literature Corpus work: 1bae0b0f-f20b-5f02-8dff-fc3da91bea68
DOI: 10.21203/rs.3.rs-66832/v3

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