Article

Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome

2021-08-16

Abstract excerpt

<h4>Background</h4> Angelman Syndrome (AS) is a rare neurodevelopmental disorder for which there is currently no cure or effective therapeutic. Since the genetic cause of AS is known to be dysfunctional expression of the maternal allele of ubiquitin protein ligase E3A ( UBE3A ), several genetic animal models of AS have been developed. Both the Ube3a maternal deletion mouse and rat models of AS reliably demonstr...

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Literature Corpus work: 59abff97-ce7d-5935-be52-5e4eb0e476c9
DOI: 10.1101/2021.08.13.456299

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