Article
Strain-dependence of the Angelman Syndrome phenotypes in Ube3a maternal deficiency mice.
Scientific reports - 16 Aug 2017
Born Heather A, Dao An T, Levine Amber T, Lee Wai Ling, Mehta Natasha M, Mehra Shubhangi, Weeber Edwin J, Anderson Anne E
Abstract excerpt
Angelman syndrome (AS) is a genetic neurodevelopmental disorder, most commonly caused by deletion or mutation of the maternal allele of the UBE3A gene, with behavioral phenotypes and seizures as key features. Currently no treatment is available, and therapeutics are often ineffective in controlling AS-associated seizures. Previous publications using the Ube3a maternal deletion model have shown behavioral and...
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