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Article

Seizure-like activity in a juvenile Angelman syndrome mouse model is attenuated by reducing Arc expression.

Proceedings of the National Academy of Sciences of the United States of America - 21 Apr 2015

Mandel-Brehm Caleigh, Salogiannis John, Dhamne Sameer C, Rotenberg Alexander, Greenberg Michael E

Abstract excerpt

Angelman syndrome (AS) is a neurodevelopmental disorder arising from loss-of-function mutations in the maternally inherited copy of the UBE3A gene, and is characterized by an absence of speech, excessive laughter, cognitive delay, motor deficits, and seizures. Despite the fact that the symptoms o...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25848016
DOI: 10.1073/pnas.1504809112
PMCID: PMC4413330

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25848016-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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