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Article

Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome.

Molecular autism - 15 Sept 2021

Berg Elizabeth L, Petkova Stela P, Born Heather A, Adhikari Anna, Anderson Anne E, Silverman Jill L

Abstract excerpt

BACKGROUND: Angelman Syndrome (AS) is a rare neurodevelopmental disorder for which there is currently no cure or effective therapeutic. Since the genetic cause of AS is known to be dysfunctional expression of the maternal allele of ubiquitin protein ligase E3A (UBE3A), several genetic animal models of AS have been developed. Both the Ube3a maternal deletion mouse and rat models of AS reliably demonstrate...

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Source

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Identifiers

PMID: 34526125
DOI: 10.1186/s13229-021-00467-1
PMCID: PMC8444390

Genes

UBE3A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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