Article
Discovering pathways through ribozyme fitness landscapes using information theoretic quantification of epistasis.
RNA (New York, N.Y.) - 1 Nov 2023
Charest Nathaniel, Shen Yuning, Lai Yei-Chen, Chen Irene A, Shea Joan-Emma
Abstract excerpt
The identification of catalytic RNAs is typically achieved through primarily experimental means. However, only a small fraction of sequence space can be analyzed even with high-throughput techniques. Methods to extrapolate from a limited data set to predict additional ribozyme sequences, particularly in a human-interpretable fashion, could be useful both for designing new functional RNAs and for generating...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.