Article
Computational analysis of fitness landscapes and evolutionary networks from in vitro evolution experiments.
Methods (San Diego, Calif.) - 15 Aug 2016
Xulvi-Brunet Ramon, Campbell Gregory W, Rajamani Sudha, Jiménez José I, Chen Irene A
Abstract excerpt
In vitro selection experiments in biochemistry allow for the discovery of novel molecules capable of specific desired biochemical functions. However, this is not the only benefit we can obtain from such selection experiments. Since selection from a random library yields an unprecedented, and sometimes comprehensive, view of how a particular biochemical function is distributed across sequence space, selection...
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