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Article

Dynamic RNA Fitness Landscapes of a Group I Ribozyme during Changes to the Experimental Environment.

Molecular biology and evolution - 2 Mar 2022

Peri Gianluca, Gibard Clémentine, Shults Nicholas H, Crossin Kent, Hayden Eric J

Abstract excerpt

Fitness landscapes of protein and RNA molecules can be studied experimentally using high-throughput techniques to measure the functional effects of numerous combinations of mutations. The rugged topography of these molecular fitness landscapes is important for understanding and predicting natural and experimental evolution. Mutational effects are also dependent upon environmental conditions, but the effects of...

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PMID: 35020916
DOI: 10.1093/molbev/msab373
PMCID: PMC8890501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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