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Article

The N-terminus of Sfi1 and yeast centrin Cdc31 provide the assembly site for a new spindle pole body.

The Journal of cell biology - 1 Mar 2021

Rüthnick Diana, Vitale Jlenia, Neuner Annett, Schiebel Elmar

Abstract excerpt

The spindle pole body (SPB) provides microtubule-organizing functions in yeast and duplicates exactly once per cell cycle. The first step in SPB duplication is the half-bridge to bridge conversion via the antiparallel dimerization of the centrin (Cdc31)-binding protein Sfi1 in anaphase. The bridge, which is anchored to the old SPB on the proximal end, exposes free Sfi1 N-termini (N-Sfi1) at its distal end. These...

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PMID: 33523111
DOI: 10.1083/jcb.202004196
PMCID: PMC7852455

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