Article
Dialogue between centrosomal entrance and exit scaffold pathways regulates mitotic commitment.
The Journal of cell biology - 4 Sept 2017
Chan Kuan Yoow, Alonso-Nuñez Marisa, Grallert Agnes, Tanaka Kayoko, Connolly Yvonne, Smith Duncan L, Hagan Iain M
Abstract excerpt
The fission yeast scaffold molecule Sid4 anchors the septum initiation network to the spindle pole body (SPB, centrosome equivalent) to control mitotic exit events. A second SPB-associated scaffold, Cut12, promotes SPB-associated Cdk1-cyclin B to drive mitotic commitment. Signals emanating from each scaffold have been assumed to operate independently to promote two distinct outcomes. We now find that signals from...
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