Article
New mutations in the core Schizosaccharomyces pombe spindle pole body scaffold Ppc89 reveal separable functions in regulating cell division.
G3 (Bethesda, Md.) - 8 Jan 2025
Hanna Sarah M, Tavafoghi Bita, Chen Jun-Song, Howard Isaac, Ren Liping, Willet Alaina H, Gould Kathleen L
Abstract excerpt
Centrosomes and spindle pole bodies (SPBs) are important for mitotic spindle formation and also serve as signaling platforms. In the fission yeast Schizosaccharomyces pombe, genetic ablation and high-resolution imaging indicate that the α-helical Ppc89 is central to SPB structure and function. Here, we developed and characterized conditional and truncation mutants of ppc89. Alleles with mutations in 2 predicted...
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