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Article

Identification of functional domains within the septation initiation network kinase, Cdc7.

The Journal of biological chemistry - 14 Apr 2006

Mehta Sapna, Gould Kathleen L

Abstract excerpt

The septation initiation network (SIN) serves to coordinate cytokinesis with mitotic exit in the fission yeast Schizosaccharomyces pombe. SIN components Spg1 and Cdc7 together play a central role in regulating the onset of septation and cytokinesis. Spg1, a Ras-like GTPase, localizes to the spindle pole bodies (SPBs) throughout the cell cycle. It is converted to its GTP-bound (active) state during mitosis, only...

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Identifiers

PMID: 16469735
DOI: 10.1074/jbc.M600160200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of functional domains within the septation initiation network kinase, Cdc7.PMID 16469735Read ↗

Mitotic hyperphosphorylation of the fission yeast SIN scaffold protein cdc11p is regulated by the protein kinase cdc7p.Semantic proximity Read ↗

Analysis of the S. pombe signalling scaffold protein Cdc11p reveals an essential role for the N-terminal domain in SIN signalling.Semantic proximity Read ↗

Timely septation requires SNAD-dependent spindle pole body localization of the septation initiation network components in the filamentous fungus Aspergillus nidulans.Semantic proximity Read ↗

Etd1p is a novel protein that links the SIN cascade with cytokinesis.Semantic proximity Read ↗

S. pombe cdc11p, together with sid4p, provides an anchor for septation initiation network proteins on the spindle pole body.Semantic proximity Read ↗

Sid2p, a spindle pole body kinase that regulates the onset of cytokinesis.Semantic proximity Read ↗

Byr4 localizes to spindle-pole bodies in a cell cycle-regulated manner to control Cdc7 localization and septation in fission yeast.Semantic proximity Read ↗

Molecular dissection of a yeast septin: distinct domains are required for septin interaction, localization, and function.Semantic proximity Read ↗

An Extended, Boolean Model of the Septation Initiation Network in S.Pombe Provides Insights into Its Regulation.Semantic proximity Read ↗

The SIN kinase Sid2 regulates cytoplasmic retention of the S. pombe Cdc14-like phosphatase Clp1.Semantic proximity Read ↗

Nuc2p, a subunit of the anaphase-promoting complex, inhibits septation initiation network following cytokinesis in fission yeast.Semantic proximity Read ↗

Proper timing of cytokinesis is regulated by Schizosaccharomyces pombe Etd1.Semantic proximity Read ↗

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