Use of Multivariable Mendelian Randomization to Address Biases Due to Competing Risk Before Recruitment

Abstract excerpt

Background:Mendelian randomization (MR) provides unconfounded estimates. MR is open to selection bias when the underlying sample is selected on surviving to recruitment on the genetically instrumented exposure and competing risk of the outcome. Few methods to address this bias exist. Methods:We show that this selection bias can sometimes be addressed by adjusting for common causes of survival and outcome. We use...

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