Article
Mendelian randomization studies on ischemic stroke: a field synopsis and systematic review.
Journal of translational medicine - 22 Aug 2025
Yang Junyi, Han Chen, Zhang Yue, Tan Shutong, Wu Qian, Ma Yumei, Duan Yuanjie, Wang Yaxin, Wang Jinke, Liu Binhui, Mu Changqing, Zhu Ruixia, Zhang Xiaoqian, Zhang Jian, Liu Xu
Abstract excerpt
BACKGROUND: Ischemic stroke (IS) is a major cause of disability and death worldwide. However, previous observational studies failed to establish the causality between various exposures and IS occurrence. Currently, an increasing number of Mendelian randomization (MR) studies have been performed to investigate the causal effects of exposure factors on IS risk, but the results remain inconsistent and inconclusive....
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