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Article

Genetically proxied appendicular lean mass and stroke risk: A two-step mendelian randomization study.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Oct 2024

Li Zhiming, Liu Xueyun, Wen Jianshang, Wang Zijie, Xie Yanfang, Zhu Lei, Wu Xiaosan, Fang Chuanqin, Tian Yanghua, Li Qi

Abstract excerpt

BACKGROUND AND PURPOSE: Prior observational studies have suggested a strong correlation between sarcopenia and stroke, but the causal link between them remains uncertain. This study aims to investigate the associations between genetically predicted sarcopenia-related traits and stroke using a two-step Mendelian randomization (MR) approach. METHODS: Genome-wide association study (GWAS) summary data for...

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PMID: 39098364
DOI: 10.1016/j.jstrokecerebrovasdis.2024.107915

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