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Tweezer PCR: A Highly Specific Method for Accurate Identification of Low-Abundance Mutations.

Analytical chemistry - 5 Dec 2023

Li Shanglin, Gu Yin, Geng Zhi, Li Kaiyi, Hu Yawei, Liu Qiang, Fu Rongxin, Liu Peng

Abstract excerpt

Somatic mutation is a valuable biomarker for tracking tumor progression and migration due to its distinctive feature in various tumors and its wide distribution throughout body fluids. However, accurately detecting somatic mutations from the abundant DNA of noncancerous origins remains a practical challenge in the clinic. Herein, we developed an ultraspecific method, called tweezer PCR, for detecting...

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PMID: 37971891
DOI: 10.1021/acs.analchem.3c03467

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