Article
Investigation on the Role of PALB2 Gene in CDH1-Negative Patients With Hereditary Diffuse Gastric Cancer.
Clinical and translational gastroenterology - 1 Dec 2020
Carreño Marta, Pena-Couso Laura, Mercadillo Fátima, Perea José, Urioste Miguel
Abstract excerpt
INTRODUCTION: Not all patients with hereditary diffuse gastric cancer (HDGC) are found to carry germline pathogenic variants in the associated gene CDH1, which translates into a challenging clinical management and poor cancer prevention. Thus, several studies have searched for other candidate gen...
Topics
- Adult
- Aged
- Antigens, CD
- Cadherins
- Fanconi Anemia Complementation Group N Protein
- Female
- Genetic Counseling
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Male
- Middle Aged
- Neoplastic Syndromes, Hereditary
- Pedigree
- Stomach Neoplasms
- Young Adult