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Article

Insertional mutagenesis using the Sleeping Beauty transposon system identifies drivers of erythroleukemia in mice.

Scientific reports - 2 Apr 2019

Loeb Keith R, Hughes Bridget T, Fissel Brian M, Osteen Nyka J, Knoblaugh Sue E, Grim Jonathan E, Drury Luke J, Sarver Aaron, Dupuy Adam J, Clurman Bruce E

Abstract excerpt

Insertional mutagenesis is a powerful means of identifying cancer drivers in animal models. We used the Sleeping Beauty (SB) transposon/transposase system to identify activated oncogenes in hematologic cancers in wild-type mice and mice that express a stabilized cyclin E protein (termed cyclin ET74AT393A). Cyclin E governs cell division and is misregulated in human cancers. Cyclin ET74AT393A mice develop...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukemia, Erythroblastic, Acute

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Source

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Identifiers

PMID: 30940846
DOI: 10.1038/s41598-019-41805-x
PMCID: PMC6445099

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Source receipt: pubmed, retrieved 7 Sept 2026.

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