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Article

Mouse models of human AML accurately predict chemotherapy response.

Genes & development - 1 Apr 2009

Zuber Johannes, Radtke Ina, Pardee Timothy S, Zhao Zhen, Rappaport Amy R, Luo Weijun, McCurrach Mila E, Yang Miao-Miao, Dolan M Eileen, Kogan Scott C, Downing James R, Lowe Scott W

Abstract excerpt

The genetic heterogeneity of cancer influences the trajectory of tumor progression and may underlie clinical variation in therapy response. To model such heterogeneity, we produced genetically and pathologically accurate mouse models of common forms of human acute myeloid leukemia (AML) and developed methods to mimic standard induction chemotherapy and efficiently monitor therapy response. We see that murine AMLs...

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Identifiers

PMID: 19339691
DOI: 10.1101/gad.1771409
PMCID: PMC2666344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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