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Article

Identification of Brain Cell Type-Specific Therapeutic Targets for Glioma From Genetics.

CNS neuroscience & therapeutics - 1 Dec 2024

Gui Jiawei, Chen Jiali, Wan Keqi, Liu Ying, Huang Kai, Zhu Xingen

Abstract excerpt

BACKGROUND: Previous research has demonstrated correlations between the complex types and functions of brain cells and the etiology of glioma. However, the causal relationship between gene expression regulation in specific brain cell types and glioma risk, along with its therapeutic implications, remains underexplored. METHODS: Utilizing brain cell type-specific cis-expression quantitative trait loci (cis-eQTLs)...

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Brain
Brain Neoplasms
Computational Biology
Genome-Wide Association Study
Glioma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

Quantitative Trait Loci

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Identifiers

PMID: 39722126
DOI: 10.1111/cns.70185
PMCID: PMC11669572

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