Article
Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.
Nature genetics - 1 Aug 2009
Wrensch Margaret, Jenkins Robert B, Chang Jeffrey S, Yeh Ru-Fang, Xiao Yuanyuan, Decker Paul A, Ballman Karla V, Berger Mitchel, Buckner Jan C, Chang Susan, Giannini Caterina, Halder Chandralekha, Kollmeyer Thomas M, Kosel Matthew L, LaChance Daniel H, McCoy Lucie, O'Neill Brian P, Patoka Joe, Pico Alexander R, Prados Michael, Quesenberry Charles, Rice Terri, Rynearson Amanda L, Smirnov Ivan, Tihan Tarik, Wiemels Joe, Yang Ping, Wiencke John K
Abstract excerpt
The causes of glioblastoma and other gliomas remain obscure. To discover new candidate genes influencing glioma susceptibility, we conducted a principal component-adjusted genome-wide association study (GWAS) of 275,895 autosomal variants among 692 adult high-grade glioma cases (622 from the San Francisco Adult Glioma Study (AGS) and 70 from the Cancer Genome Atlas (TCGA)) and 3,992 controls (602 from AGS and...
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