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Article

Visual Memory Deficits in Middle-Aged APOEɛ4 Homozygotes Detected Using Unsupervised Cognitive Assessments.

Journal of Alzheimer's disease : JAD - 1 Jan 2021

Lim Yen Ying, Pase Matthew P, Buckley Rachel F, Yassi Nawaf, Bransby Lisa, Fowler Christopher, Laws Simon M, Masters Colin L, Maruff Paul

Abstract excerpt

BACKGROUND: The apolipoprotein E (APOE) ɛ4 allele is associated with dose-response effects on cognitive dysfunction and dementia risk in older adults. However, its effects on cognition in middle-aged adults remains unclear. OBJECTIVE: We examined effects of ɛ4 heterozygosity and homozygosity on objective and subjective cognition in middle-aged adults enrolled in the Healthy Brain Project (HBP) and in older adults...

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PMID: 33492293
DOI: 10.3233/JAD-201281

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