Article
Supervised mutational signatures for obesity and other tissue-specific etiological factors in cancer.
eLife - 25 Jan 2021
Afsari Bahman, Kuo Albert, Zhang YiFan, Li Lu, Lahouel Kamel, Danilova Ludmila, Favorov Alexander, Rosenquist Thomas A, Grollman Arthur P, Kinzler Ken W, Cope Leslie, Vogelstein Bert, Tomasetti Cristian
Abstract excerpt
Determining the etiologic basis of the mutations that are responsible for cancer is one of the fundamental challenges in modern cancer research. Different mutational processes induce different types of DNA mutations, providing 'mutational signatures' that have led to key insights into cancer etiology. The most widely used signatures for assessing genomic data are based on unsupervised patterns that are then...
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