Article

Integrated single-nucleotide and structural variation signatures of DNA-repair deficient human cancers

2018-02-18

Abstract excerpt

Mutation signatures in cancer genomes reflect endogenous and exogenous mutational processes, offering insights into tumour etiology, features for prognostic and biologic stratification and vulnerabilities to be exploited therapeutically. We present a novel machine learning formalism for improved signature inference, based on multi-modal correlated topic models (MMCTM) which can at once infer signatures from both s...

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Literature Corpus work: 6dfe6b4d-7937-55c6-ba98-62f9fb5c32fc
DOI: 10.1101/267500

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