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Article

Mutational signatures among young-onset testicular cancers.

BMC medical genomics - 24 Nov 2021

Mealey Nicole E, O'Sullivan Dylan E, Peters Cheryl E, Heng Daniel Y C, Brenner Darren R

Abstract excerpt

BACKGROUND: Incidence of testicular cancer is highest among young adults and has been increasing dramatically for men born since 1945. This study aimed to elucidate the factors driving this trend by investigating differences in mutational signatures by age of onset. METHODS: We retrieved somatic variant and clinical data pertaining to 135 testicular tumors from The Cancer Genome Atlas. We compared mutational...

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Identifiers

PMID: 34819066
DOI: 10.1186/s12920-021-01121-8
PMCID: PMC8611954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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