Article
Not Quite Lost in Translation: Mistranslation Alters Adaptive Landscape Topography and the Dynamics of Evolution.
Molecular biology and evolution - 1 Jun 2023
Schmutzer Michael, Wagner Andreas
Abstract excerpt
Mistranslation-the erroneous incorporation of amino acids into nascent proteins-is a source of protein variation that is orders of magnitude more frequent than DNA mutation. Like other sources of nongenetic variation, it can affect adaptive evolution. We study the evolutionary consequences of mistranslation with experimental data on mistranslation rates applied to three empirical adaptive landscapes. We find that...
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