Mistranslation Reduces Mutation Load in Evolving Proteins through Negative Epistasis with DNA Mutations.

doi:10.1093/molbev/msab206

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Article

Mistranslation Reduces Mutation Load in Evolving Proteins through Negative Epistasis with DNA Mutations.

Molecular biology and evolution - 27 Oct 2021

Zheng Jia, Guo Ning, Wagner Andreas

Abstract excerpt

Translational errors during protein synthesis cause phenotypic mutations that are several orders of magnitude more frequent than DNA mutations. Such phenotypic mutations may affect adaptive evolution through their interactions with DNA mutations. To study how mistranslation may affect the adaptive evolution of evolving proteins, we evolved populations of green fluorescent protein (GFP) in either...

Topics

DNA
Epistasis, Genetic
Escherichia coli
Evolution, Molecular
Mutation
Selection, Genetic

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Identifiers

PMID: 34255074
DOI: 10.1093/molbev/msab206
PMCID: PMC8557407

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