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Article

Apolipoprotein E genotypes and amyloid burden associated with cognitive decline in non-demented Parkinson's disease patients: A preliminary analysis.

Journal of the neurological sciences - 15 Jun 2025

Trompeta Clara, Gasca-Salas Carmen, Rodríguez-Rojas Rafael, Fernández-Rodríguez Beatriz, Clarimón Jordi, García-Cañamaque Lina, Guida Pasqualina, Hernández-Fernández Frida, Sánchez-Juan Pascual, Olazarán Javier, Vela-Desojo Lydia

Abstract excerpt

BACKGROUND: Cognitive impairment is a common non-motor manifestation in Parkinson's disease (PD). Amyloidosis seems to accelerate the onset of dementia in PD. The Apolipoprotein (APOE) ε4 genotype is linked to amyloid aggregation and has been suggested to be a candidate for development of PD dementia, while other APOE alleles have been less investigated. METHODS: Forty-eight non-demented PD patients were included...

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Identifiers

PMID: 40300362
DOI: 10.1016/j.jns.2025.123510

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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