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Article

Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming

1 Jan 2014

Abstract excerpt

In the early twentieth century, Otto Heinrich Warburg described an elevated rate of glycolysis occurring in cancer cells, even in the presence of atmospheric oxygen (the Warburg effect). Despite the inefficiency of ATP generation through glycolysis, the breakdown of glucose into lactate provides cancer cells with a number of advantages, including the ability to withstand fluctuations in oxygen levels, and the...

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PMID: 25085992
DOI: 10.1242/dmm.016287

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