Article
Autoimmune experimental orchitis and chronic glomerulonephritis with end stage renal disease are controlled by Cgnz1 for susceptibility to end organ damage.
Clinical immunology (Orlando, Fla.) - 1 Mar 2021
Zhao Zhenhuan, Qiao Hui, Ge Y, Kannapel C C, Sung Sun-Sang J, Gaskin Felicia, Tung Kenneth S K, Fu Shu Man
Abstract excerpt
Cgnz1 on chromosome 1 mapped into a 1.34 Mb region of chromosome 1 in NZM2328 confers the progression of immune complex (IC)-mediated glomerulonephritis (GN) from acute GN (aGN) to chronic GN (cGN) with severe proteinuria and end stage renal disease in female mice. This genetic locus mediates podocyte susceptibility to IC-mediated damage. Taking advantage of the published observation that Cgnz1 is derived from...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.