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Article

Insulin acutely activates metabolism of primary human monocytes and promotes a proinflammatory phenotype.

Journal of leukocyte biology - 1 Nov 2021

Ratter Jacqueline M, van Heck Julia I P, Rooijackers Hanne M M, Jansen Henry J, van Poppel Pleun C M, Tack Cees J, Stienstra Rinke

Abstract excerpt

Increased glycolysis is a metabolic trait of activated innate immune cells and supports functional changes including cytokine production. Insulin drives glycolysis in nonimmune cells, yet its metabolic effects on human innate immune cells remain unexplored. Potential effects of insulin on immune cell metabolism may occur acutely after a postprandial increase in plasma insulin levels or as a consequence of...

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Identifiers

PMID: 33477205
DOI: 10.1002/JLB.3AB0120-019RR

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