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Article

Immunoregulatory effect of metformin in monocytes exposed to SARS-CoV-2 spike protein subunit 1

2025-09-12

Abstract excerpt

<h4>Background</h4> Severe COVID-19 is characterized by a hyperinflammatory state associated with an exacerbated inflammatory activation of monocytes and macrophages in the respiratory tract. Metformin has been identified as a potent monocyte inflammatory suppressor, and it has been demonstrated to attenuate inflammation in COVID-19. The mechanisms underlying metformin anti-inflammatory effects are, however, uncl...

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Literature Corpus work
41fde217-f03d-5db5-a43d-9d1c918e5236
DOI
10.1101/2025.09.12.675877
Open publication

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Immunoregulatory effect of metformin in monocytes exposed to SARS-CoV-2 spike protein subunit 1DOI 10.1101/2025.09.12.675877
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