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Article

CEP55 promotes cilia disassembly through stabilizing Aurora A kinase.

The Journal of cell biology - 1 Feb 2021

Zhang Yu-Cheng, Bai Yun-Feng, Yuan Jin-Feng, Shen Xiao-Lin, Xu Yu-Ling, Jian Xiao-Xiao, Li Sen, Song Zeng-Qing, Hu Huai-Bin, Li Pei-Yao, Tu Hai-Qing, Han Qiu-Ying, Wang Na, Li Ai-Ling, Zhang Xue-Min, Wu Min, Zhou Tao, Li Hui-Yan

Abstract excerpt

Primary cilia protrude from the cell surface and have diverse roles during development and disease, which depends on the precise timing and control of cilia assembly and disassembly. Inactivation of assembly often causes cilia defects and underlies ciliopathy, while diseases caused by dysfunction in disassembly remain largely unknown. Here, we demonstrate that CEP55 functions as a cilia disassembly regulator to...

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Identifiers

PMID: 33475699
DOI: 10.1083/jcb.202003149
PMCID: PMC7829976

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