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Article

CPAP promotes timely cilium disassembly to maintain neural progenitor pool.

The EMBO journal - 15 Apr 2016

Gabriel Elke, Wason Arpit, Ramani Anand, Gooi Li Ming, Keller Patrick, Pozniakovsky Andrei, Poser Ina, Noack Florian, Telugu Narasimha Swamy, Calegari Federico, Šarić Tomo, Hescheler Jürgen, Hyman Anthony A, Gottardo Marco, Callaini Giuliano, Alkuraya Fowzan Sami, Gopalakrishnan Jay

Abstract excerpt

A mutation in the centrosomal-P4.1-associated protein (CPAP) causes Seckel syndrome with microcephaly, which is suggested to arise from a decline in neural progenitor cells (NPCs) during development. However, mechanisms ofNPCs maintenance remain unclear. Here, we report an unexpected role for the cilium inNPCs maintenance and identifyCPAPas a negative regulator of ciliary length independent of its role in...

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Identifiers

PMID: 26929011
DOI: 10.15252/embj.201593679
PMCID: PMC4972140

Genes

CPAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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