Article
Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies.
Structure (London, England : 1993) - 6 Jan 2022
Rosa E Silva Ivan, Binó Lucia, Johnson Christopher M, Rutherford Trevor J, Neuhaus David, Andreeva Antonina, Čajánek Lukáš, van Breugel Mark
Abstract excerpt
Cilia formation is essential for human life. One of the earliest events in the ciliogenesis program is the recruitment of tau-tubulin kinase 2 (TTBK2) by the centriole distal appendage component CEP164. Due to the lack of high-resolution structural information on this complex, it is unclear how it is affected in human ciliopathies such as nephronophthisis. Furthermore, it is poorly understood if binding to CEP164...
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